Analysis Note

single spot by TLC

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary Targetcaspase-8

Cell permeable: yes

General description

A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218759) in DMSO. Z-IETD-FMK is a potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345.Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.

Packaging

Packaged under inert gas

250 µg in Glass bottle

Physical form

A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218759) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Sequence

Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*

Warning

Toxicity: Irritant (B)